Warfarin: MedlinePlus Drug Information
CYP2C9 is the major enzyme catalyzing the 6- and 7-hydroxylation of S-warfarin while 4′-hydroxylation occurs through CYP2C18 with minor contributions from CYP2C19. The 10-hydroxywarfarin metabolite as well as a benzylic alcohol metabolite undergo an elimination step to form dehydrowarfarin. The minor pathway of metabolism is the reduction of the ketone group to warfarin alcohols, comprising […]
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